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Endosense’s TactiCath ablation catheter has undergone extensive preclinical testing in the United States and Europe. Initial data has indicated that real-time contact force measurement with TactiCath may have a major positive impact on the safety and efficacy of the catheter ablation procedure, while improving physician decision-making and potentially shortening procedure time. It has also shown a high correlation between the calibrated force applied during catheter ablation and the TactiCath force sensor output.

Endosense’s growing body of study data has been the subject of twelve abstracts presented at annual meetings of the Heart Rhythm Society, American College of Cardiology and American Heart Association

Catheter Contact Force during Human Right and Left Atrial Mapping in Humans

Heart Rhythm Society, May 2009, Boston, MA, Abstract P004-25

Dipen C. Shah, MD, PhD, Boris Schmidt, MD, Thomas Arentz, MD, Karl-Heinz Kuck, MD, PhD, Peter Neuzil, MD, Gabriel Latcu, MD, Gerhard Hindricks , MD, PhD, Joseph Kautzner, MD, Nicolas Aeby, Hendrik Lambert, PhD
Hôpital Universitaire de Genève, Geneva, Switzerland, Herzzentrum Bad Krozingen, Bad Krozingen, Germany, Asklepios Klinik St. Georg, Hamburg, Germany, Na Homolce Hospital, Prague, Czech Republic, Centre Hospitalier Princesse Grace, Monaco , Herzzentrum Leipzig, Leipzig, Germany, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic, Endosense, Geneva, Switzerland

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Toccata Multi-Center Clinical Study Using Irrigated Ablation Catheter with Integrated Contact Force Sensor: First Results

Heart Rhythm Society, May 2009, Boston, MA, Abstract #6293

Boris Schmidt, MD, Karl-Heinz Kuck, MD, PhD, Dipen Shah, MD, PhD, Vivek Reddy, MD, Nadir Saoudi, MD, PhD, Claudia Herrera, MD, Gerhard Hindricks, MD, PhD, Andrea Natale, MD, PhD, Pierre Jaïs, MD, PhD, Hendrik Lambert, PhD
Asklepios Klinik St. Georg, Hamburg, Germany, Hôpital Universitaire de Genève, Geneva, Switzerland, University of Miami Hospital, Miami, FL, Centre Hospitalier Princesse Grace, Monaco, Herzzentrum Bad Krozingen, Bad Krozingen, Germany, Herzzentrum Leipzig, Leipzig, Germany, Texas Cardiac Arrhythmia Institute, Austin, TX, Hôpital Haut Lévêque, Bordeaux, France, Endosense SA, Geneva, Switzerland

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Force-Time Integral Predicts Lesion Size in Contractile Model Simulating Beating Heart

Heart Rhythm Society, May 2009, Boston, USA, , Abstract PO01-46, Abstract 6293, Abstract PO04-25

Dipen C. Shah, MD, PhD, Hendrik Lambert, PhD, Hiroshi Nakagawa, MD, PhD, Arne Langenkamp, Nicolas Aeby, Yuri Vanenkov
Hôpital Universitaire de Genève, Geneva, Switzerland, Cardiac Arrhythmia Research Institute, University of Oklahoma, Oklahoma City, Oklahoma, USA, Endosense, Geneva, Switzerland

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Evaluation of a New Catheter Sensor for Real-Time Measurement of Tissue Contact

Heart Rhythm Society, May 2006, Boston, USA -Vol. 3, Issue 5 (Supplement), S75-S76, AB36-6

Dipen C. Shah, MD, Giovanni Leo, Nicolas Aeby, Eric Le Royer, Henri Sunthorn, Haran Burri, MD, Pascal Gentil-Baron 
Hospital Cantonal De Geneve, Geneva, Switzerland, Endosense, Geneva, Switzerland

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Novel Radiofrequency Ablation Catheter with Contact Force Sensor Predicts Lesion Size and Incidence of Steam Pop in Canine Model

Heart Rhythm Society, May 2007, Denver, USA -Vol. 4, Issue 5 (Supplement), S340-S341, PO5-106

Katsuaki Yokoyama, MD, PhD, Hiroshi Nakagawa, MD, PhD, Dipen C. Shah, MD, Hendrik Lambert, PhD, Giovanni Leo, Nicolas Aeby, Jan V. Pitha, MD, PhD, Ralph Lazzara, MD, Warren M. Jackman, MD
Cardiac Arrhythmia Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA, Hospital Cantonal De Geneve, Geneva, Switzerland,Endosense, Geneva, Switzerland

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The Relationship between Impedance Change and Catheter Contact Force During Radiofrequency Ablation: Evaluation in a Porcine Ex Vivo Cardiac Model Using a Novel Force-Sensing Irrigated Tip Ablation Catheter

American Heart Association, November 2007, Chicago, USA -Circulation. 116(2):487, Abstract 2239

Aravinda Thiagalingam, Andre d’Avila, Lori Foley, Melodie Fox, Hendrik Lambert, PhD, Giovanni Leo, Jeremy N. Ruskin, Vivek Y. Reddy
Massachusetts General Hospital, Boston, MA, Endosense, Geneva, Switzerland

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Real Time Monitoring of Tip Electrode-Tissue Orientation and Contact Force: Optimizing Accuracy and Safety of Mapping and Ablation Procedures

American College of Cardiology, March 2008, Orlando, USA

Luigi Di Biase, Mauricio Arruda, Luciana Armaganijan, Moataz El Hallage, Dimpi Patel, Mohamed Kanj, Oussama M. Wazni, Thomas Dresing, Jennifer E. Cummings, Mandeep Bhargava, J. David Burkhardt, David O. Martin, Walid I. Saliba, Robert A. Schweikert, Andrea Natale 
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA

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Electrogram Parameters (Injury Current, Amplitude and dV/dt) and Impedance are Poor Predictors of Electrode-Tissue Contact Force for Radiofrequency Ablation

Heart Rhythm Society, May 2008, San Francisco, USA, Abstract 4570, PO5-41

Atsushi Ikeda, MD, PhD, Hiroshi Nakagawa, MD, PhD, Dipen C. Shah, MD, Hendrik Lambert, PhD, Yury Vanenkov, Nicolas Aeby, Jan V. Pitha, MD, PhD, Warren M. Jackman, MD 
Cardiac Arrhythmia Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA, Hospital Cantonal De Geneve, Geneva, Switzerland, Endosense, Geneva, Switzerland

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Radiofrequency Ablation Catheter With Contact Force Sensor Predicts Lesion Size and Incidence of Steam Pop in the Beating Canine Heart

Heart Rhythm Society, May 2008, San Francisco, USA, Abstract 4543, PO1-57

Atsushi Ikeda, MD, PhD, Hiroshi Nakagawa, MD, PhD, Dipen C. Shah, MD*, Hendrik Lambert, PhD**, Giovanni Leo**, Nicolas Aeby**, Jan V. Pitha, MD, PhD, Warren M. Jackman, MD 
Cardiac Arrhythmia Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA, * Hospital Cantonal De Geneve, Geneva, Switzerland, **Endosense, Geneva, Switzerland

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Role of Contact Force in Esophageal Injury During Left Atrial Radiofrequency Ablation

Heart Rhythm Society, May 2008, San Francisco, USA, Abstract 6317, PO5-26

Atsushi Ikeda, MD, PhD, Hiroshi Nakagawa, MD, PhD, Dipen C. Shah, MD, Hendrik Lambert, PhD, Giovanni Leo, Kenneth A. Seres, MD, Tushar Sharma, MD, Jaime Merino, MSc, Eugene Jung, BSc, Jan V. Pitha, MD, PhD, Warren M. Jackman, MD
Cardiac Arrhythmia Research Institute and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, *Hospital Cantonal De Geneve, Geneva, Switzerland, Endosense, Geneva, Switzerland,

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Correlation of Real Time Measurement of Ablation Catheter Tip Force with Subjective Tissue Contact Assessment in the Beating Heart

Heart Rhythm Society, May 2008, San Francisco, USA, Abstract 6099, PO1-67

Dipen C. Shah, MD, Hendrik Lambert, PhD, Hiroshi Nakagawa, MD, PhD, Beat Walpoth, MD, Nadir Saoudi, MD, Nicolas Aeby, Giovanni Leo, Pascale Gentil-Baron
Hospital Cantonal De Geneve, Geneva, Switzerland, Cardiac Arrhythmia Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA, Centre Hospitalier Princesse Grace, Monaco, Endosense, Geneva, Switzerland

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Catheter Tip Force Required to Mechanically Perforate the Cardiac Free Wall

Heart Rhythm Society, May 2008, San Francisco, USA, Abstract 6127, PO1-68, Abstract 6099, PO1-67, Abstract 6317, PO5-26, Abstract 4543, PO1-57, Abstract 4570, PO5-41

Dipen C. Shah, MD, Hendrik Lambert, PhD, Nadir Saoudi, MD, Yury Vanenkov, Beat Walpoth, MD, Nicolas Aeby, Pascale Gentil-Baron
Hospital Cantonal De Geneve, Geneva, Switzerland, Centre Hospitalier Princesse Grace, Monaco,Endosense, Geneva, Switzerland

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Novel Contact Force Sensor Incorporated in Irrigated Radiofrequency Ablation Catheter Predicts Lesion Size and Incidence of Steam Pop and Thrombus

Circulation : Arrhythmia and Electrophysiology 2008, 10.1161/CIRCEP.108.807925

Katsuaki Yokoyama; Hiroshi Nakagawa; Dipen C. Shah; Hendrik Lambert; Giovanni Leo; Nicolas Aeby; Atsushi Ikeda; Jan V. Pitha; Tushar Sharma; Ralph Lazzara and Warren M. Jackman
University of Oklahoma and Veterans Administration Medical Center, Oklahoma City, OK; Hospital Cantonal De Geneve, Geneva, Switzerland; Endosense, Geneva, Switzerland; Heart Rhythm Institute, Department of Medicine and Pathology, Oklahoma City, OK.

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